PMID- 20799451
OWN - NLM
STAT- MEDLINE
DA  - 20100830
DCOM- 20101008
LR  - 20120828
VI  - 96
DP  - 2009
TI  - Potential uses of NIR and IR spectroscopy in quality control of allergy vaccine
      production.
PG  - 112-9; discussion 120
AB  - BACKGROUND: Compared to conventional methods, infrared spectroscopy offers many
      potential uses in quality control of vaccine production. A major advantage is
      that the technique is non-invasive and non-destructive. In this study several
      possible uses of infrared spectroscopy in the control of allergy vaccines were
      investigated. METHODS: Near infrared spectroscopy (NIR) was applied to determine 
      the aluminium content in aluminium hydroxide formulations, the particle size of
      aluminium hydroxide, the protein adsorption level on aluminium adjuvant and the
      moisture content of lyophilized vaccines. Mid infrared spectroscopy (IR) was used
      to investigate protein structural changes during adsorption and release from
      aluminium hydroxide and the stability of the complex. RESULTS: Based on the
      calibration models of NIR in different applications, it was demonstrated that NIR
      had great advantages for application in vaccine production. IR also showed
      advantages on structural analysis of adsorbed proteins. DISCUSSION: Infrared
      spectroscopy as a physical, non-invasive, non-destructive method should receive
      more attention in vaccine research and production.
AD  - ALK-Abello A/S, Guangzhou, PR China.
FAU - Zheng, Yiwu
AU  - Zheng Y
FAU - Lai, Xuxin
AU  - Lai X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess
JT  - Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut fur Impfstoffe und
      biomedizinische Arzneimittel) Langen/Hessen
JID - 101590917
RN  - 0 (Allergens)
RN  - 0 (Proteins)
RN  - 0 (Vaccines)
RN  - 21645-51-2 (Aluminum Hydroxide)
RN  - 7429-90-5 (Aluminum)
SB  - IM
MH  - Allergens/*analysis/chemistry/therapeutic use
MH  - Aluminum/analysis
MH  - Aluminum Hydroxide
MH  - Desensitization, Immunologic
MH  - Humans
MH  - Particle Size
MH  - Protein Stability
MH  - Proteins/chemistry/immunology
MH  - Quality Control
MH  - Spectrophotometry, Infrared
MH  - Spectroscopy, Near-Infrared
MH  - Vaccines/*standards/therapeutic use
EDAT- 2009/01/01 00:00
MHDA- 2010/10/12 06:00
CRDT- 2010/08/31 06:00
PST - ppublish
SO  - Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess.
      2009;96:112-9; discussion 120.