PMID- 7216443
OWN - NLM
STAT- MEDLINE
DA  - 19810623
DCOM- 19810623
LR  - 20091118
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 31
IP  - 1
DP  - 1981 Jan
TI  - Evaluation of the role of the pneumococcal Forssman antigen (F-polysaccharide) in
      the cross-serotype protection induced by pneumococcal subcellular preparations.
PG  - 169-73
AB  - We tested the hypothesis that the capacity of subcellular preparations of rough
      pneumococci to give cross-serotype protection is due to the presence of the
      pneumococcal Forssman antigen (F-polysaccharide). We found by hemagglutination
      inhibition that the Forssman antigen is present in the subcellular extracts.
      However, we concluded that the Forssman antigen is not the protective immunogen
      in the pneumococcal subcellular preparation, since absorption with sheep
      erythrocytes failed to remove the protective capacity from antiserum raised
      against the vaccine. Other evidence mitigating against the pneumococcal Forssman 
      antigen being the protective immunogen included the absence of a detectable
      hemolytic titer in protective antiserum raised against the subcellular
      preparation, the failure of high-titered sheep hemolysin to passively protect
      mice against pneumococcal infection, and the failure of purified F-polysaccharide
      to immunize mice against pneumococcal infection.
FAU - Au, C C
AU  - Au CC
FAU - Einsenstein, T K
AU  - Einsenstein TK
LA  - eng
GR  - AI-11860/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - UNITED STATES
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Vaccines)
RN  - 9013-60-9 (Forssman Antigen)
SB  - IM
MH  - Animals
MH  - Antigens, Bacterial/*immunology
MH  - Bacterial Vaccines/*immunology
MH  - Cross Reactions
MH  - Female
MH  - Forssman Antigen/*immunology
MH  - Immunization, Passive
MH  - Mice
MH  - Pneumococcal Infections/*immunology
MH  - Ribosomes/immunology
MH  - Serotyping
MH  - Streptococcus pneumoniae/classification/*immunology
MH  - Subcellular Fractions/immunology
PMC - PMC351766
OID - NLM: PMC351766
EDAT- 1981/01/01
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PST - ppublish
SO  - Infect Immun. 1981 Jan;31(1):169-73.