PMID- 6279510 OWN - NLM STAT- MEDLINE DA - 19820614 DCOM- 19820614 LR - 20091118 IS - 0019-9567 (Print) IS - 0019-9567 (Linking) VI - 35 IP - 3 DP - 1982 Mar TI - Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin. PG - 1018-23 AB - Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test. FAU - Watanabe, M AU - Watanabe M FAU - Nakase, Y AU - Nakase Y LA - eng PT - Journal Article PL - UNITED STATES TA - Infect Immun JT - Infection and immunity JID - 0246127 RN - 0 (Bacterial Toxins) RN - 0 (Hemagglutinins) RN - 51-45-6 (Histamine) SB - IM MH - Agglutination MH - Bacterial Toxins/biosynthesis MH - Bordetella pertussis/genetics/*immunology/pathogenicity MH - Hemagglutinins/*immunology MH - Histamine/pharmacology MH - Leukocytosis/etiology MH - Mutation PMC - PMC351149 OID - NLM: PMC351149 EDAT- 1982/03/01 MHDA- 1982/03/01 00:01 CRDT- 1982/03/01 00:00 PST - ppublish SO - Infect Immun. 1982 Mar;35(3):1018-23.