PMID- 6823748
OWN - NLM
STAT- MEDLINE
DA  - 19830324
DCOM- 19830324
LR  - 20071114
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 124
IP  - 2
DP  - 1983 Jan 30
TI  - Chemical and immunological analysis of the rabies soluble glycoprotein.
PG  - 330-7
AB  - Soluble glycoprotein (Gs), purified from virion-depleted, rabies-infected tissue 
      culture fluid, was chemically and immunologically analyzed. A comparison of this 
      antigen with the virion-associated glycoprotein showed that Gs lacks 58 amino
      acid residues from the carboxy terminus of the virion-associated glycoprotein.
      Analysis with monoclonal antibodies revealed that all the epitopes of the viral
      glycoprotein are also present in the soluble glycoprotein. However, when tested
      for its ability to protect mice against a lethal challenge infection with rabies 
      virus, Gs in contrast to viral glycoprotein, showed no protective activity. These
      results suggest that the carboxy terminus of the rabies virus glycoprotein is
      necessary for its full protective activity even though this portion of the
      glycoprotein molecule does not contain any antigenic determinants.
FAU - Dietzschold, B
AU  - Dietzschold B
FAU - Wiktor, T J
AU  - Wiktor TJ
FAU - Wunner, W H
AU  - Wunner WH
FAU - Varrichio, A
AU  - Varrichio A
LA  - eng
GR  - AI-09706/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - UNITED STATES
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Glycoproteins/*analysis/immunology/isolation & purification
MH  - Immunization
MH  - Mice
MH  - Molecular Weight
MH  - Rabies/prevention & control
MH  - Rabies virus/*analysis
MH  - Solubility
MH  - Structure-Activity Relationship
MH  - Viral Proteins/*analysis/immunology/isolation & purification
EDAT- 1983/01/30
MHDA- 1983/01/30 00:01
CRDT- 1983/01/30 00:00
PST - ppublish
SO  - Virology. 1983 Jan 30;124(2):330-7.