PMID- 3480536
OWN - NLM
STAT- MEDLINE
DA  - 19880220
DCOM- 19880220
LR  - 20091118
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 84
IP  - 24
DP  - 1987 Dec
TI  - Induction of protective immunity against rabies by immunization with rabies virus
      ribonucleoprotein.
PG  - 9165-9
AB  - We have studied the ability of rabies virus ribonucleoprotein (RNP) to induce a
      protective immune response in animals against lethal challenge with rabies and
      rabies-related lyssa viruses. Liposomes containing either RNP or the glycoprotein
      (G protein) of a variant virus with multiple alterations in the G antigenic
      structure conferred no or poor protection, respectively, against lethal
      intracerebral challenge with rabies virus. By contrast, liposomes containing RNP 
      and the variant G protein induced a good protective response, comparable to that 
      achieved with inactivated virus vaccine against intracerebral challenge.
      Moreover, mice or raccoons immunized with RNP alone resisted lethal peripheral
      challenge with homologous or heterologous virus strains. These results indicate
      that the RNP of rabies virus plays a crucial role in induction of protective
      immunity.
AD  - Wistar Institue of Anatomy and Biology, Philadelphia, PA 19104.
FAU - Dietzschold, B
AU  - Dietzschold B
FAU - Wang, H H
AU  - Wang HH
FAU - Rupprecht, C E
AU  - Rupprecht CE
FAU - Celis, E
AU  - Celis E
FAU - Tollis, M
AU  - Tollis M
FAU - Ertl, H
AU  - Ertl H
FAU - Heber-Katz, E
AU  - Heber-Katz E
FAU - Koprowski, H
AU  - Koprowski H
LA  - eng
GR  - AI-09706-16/AI/NIAID NIH HHS/United States
GR  - AI-22528/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - UNITED STATES
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Oligopeptides)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*biosynthesis
MH  - Antigens, Viral/*immunology
MH  - Mice
MH  - Neutralization Tests
MH  - Oligopeptides/chemical synthesis/immunology
MH  - Rabies/*prevention & control
MH  - Rabies virus/*immunology
MH  - Raccoons
MH  - Ribonucleoproteins/*immunology
MH  - Vaccination
MH  - Viral Vaccines/*immunology
PMC - PMC299713
OID - NLM: PMC299713
EDAT- 1987/12/01
MHDA- 1987/12/01 00:01
CRDT- 1987/12/01 00:00
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1987 Dec;84(24):9165-9.