PMID- 2668197
OWN - NLM
STAT- MEDLINE
DA  - 19890920
DCOM- 19890920
LR  - 20071114
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 89
IP  - 2-3
DP  - 1989
TI  - Immunogenicity of three recombinant Treponema pallidum antigens examined in
      guinea pigs.
PG  - 128-35
AB  - The immunogenicity of recombinant treponemal antigens TmpA, TmpB and TmpC
      incorporated in RIBI adjuvant and injected into inbred strain 2 guinea pigs has
      been examined. The immune status of these animals has been challenged by
      infection with Treponema pallidum, Nichols. The immune response evaluated by the 
      fluorescent-antibody test, microhemagglutination test and ELISA demonstrated high
      titers of antibodies to the T. pallidum antigens. The immunoblot analysis proved 
      that the antibodies were directed to the 43-(Tmp A) 34- (Tmp B) and 35-kdalton
      (Tmp C) polypeptides. Antibodies cross-reacting with Treponema phagedenis biotype
      Reiter were, however, also detected. In spite of high titers of antibodies the
      animals were not protected against challenging infection with 10(8) organisms of 
      T. pallidum.
AD  - Wadsworth Center for Laboratories and Research, New York State Department of
      Health, Albany.
FAU - Wicher, K
AU  - Wicher K
FAU - van Embden, J D
AU  - van Embden JD
FAU - Schouls, L M
AU  - Schouls LM
FAU - Zabek, J
AU  - Zabek J
FAU - Jakubowski, A
AU  - Jakubowski A
FAU - Wicher, V
AU  - Wicher V
LA  - eng
GR  - AI-21833/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - SWITZERLAND
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Vaccines)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Animals
MH  - Antibodies, Protozoan/biosynthesis
MH  - Antigens, Protozoan/genetics/*immunology
MH  - Blotting, Western
MH  - Guinea Pigs
MH  - Recombinant Proteins/immunology
MH  - Syphilis/immunology/prevention & control
MH  - Treponema pallidum/*immunology
MH  - Vaccines/*immunology
MH  - Vaccines, Synthetic/*immunology
EDAT- 1989/01/01
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1989;89(2-3):128-35.