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Homesaletalksslamtraining-201506day-3-advanced-and-mimirmodule-4-mimirfastvacpubmed-corpus-672 〉 Q2_iteration3_MEDLINE-xx06.pubmed.txt
 
PMID- 1433267
OWN - NLM
STAT- MEDLINE
DA  - 19921201
DCOM- 19921201
LR  - 20061115
IS  - 0047-2565 (Print)
IS  - 0047-2565 (Linking)
VI  - 21
IP  - 2-3
DP  - 1992 Feb-May
TI  - Protection against SIV infection in macaques by immunization with inactivated
      virus from the BK28 molecular clone, but not with BK28-derived recombinant env
      and gag proteins.
PG  - 50-8
AB  - Vaccination of cynomolgus macaques with beta-propiolactone inactivated SIVmacBK28
      in Freund's adjuvant induced low but detectable levels of anti-SIV envelope (env)
      antibodies and T-cell responses and protected against challenge with the 32H
      isolate of SIVmac251 grown in C8166 cells. In contrast, purified recombinant SIV 
      env and gag proteins derived from BK28 formulated in Syntex adjuvant generated
      consistent and long-lived cellular and humoral immune responses to SIV env, but
      failed to protect against infection with the 32H virus. Thus, protection against 
      a heterogeneous challenge stock is possible by immunization with a
      molecularly-cloned virus, but not with recombinant proteins from the same
      molecular origin. High levels of anti-cell antibodies induced by the whole virus 
      vaccine, but not by recombinant proteins, may have contributed to the protection 
      observed.
AD  - National Institute for Biological Standards and Control, Potters Bar,
      Hertfordshire, U.K.
FAU - Mills, K H
AU  - Mills KH
FAU - Page, M
AU  - Page M
FAU - Chan, W L
AU  - Chan WL
FAU - Kitchin, P
AU  - Kitchin P
FAU - Stott, E J
AU  - Stott EJ
FAU - Taffs, F
AU  - Taffs F
FAU - Jones, W
AU  - Jones W
FAU - Rose, J
AU  - Rose J
FAU - Ling, C
AU  - Ling C
FAU - Silvera, P
AU  - Silvera P
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - DENMARK
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
RN  - 0 (Antibodies, Viral)
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, gag)
RN  - 0 (Interleukin-2)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Vaccines, Synthetic)
RN  - 0 (Viral Vaccines)
SB  - IM
SB  - X
MH  - Animals
MH  - Antibodies, Viral/biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Products, env/*immunology
MH  - Gene Products, gag/*immunology
MH  - Immunity, Cellular
MH  - Immunoblotting
MH  - Interleukin-2/biosynthesis
MH  - Lymphocyte Activation
MH  - *Macaca fascicularis
MH  - Neutralization Tests
MH  - Simian Acquired Immunodeficiency Syndrome/immunology/*prevention & control
MH  - Simian immunodeficiency virus/*immunology
MH  - T-Lymphocytes/immunology
MH  - Vaccination/veterinary
MH  - Vaccines, Inactivated/immunology
MH  - Vaccines, Synthetic/immunology
MH  - Viral Vaccines/immunology
EDAT- 1992/02/01
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PST - ppublish
SO  - J Med Primatol. 1992 Feb-May;21(2-3):50-8.