PMID- 1730501
OWN - NLM
STAT- MEDLINE
DA  - 19920218
DCOM- 19920218
LR  - 20091118
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 60
IP  - 2
DP  - 1992 Feb
TI  - Immunization against anthrax with Bacillus anthracis protective antigen combined 
      with adjuvants.
PG  - 662-8
AB  - The protective efficacy of immunization against anthrax with Bacillus anthracis
      protective antigen (PA) combined with different adjuvants was tested in Hartley
      guinea pigs and CBA/J and A/J mice. Adjuvant components derived from microbial
      products that were tested included threonyl-muramyl dipeptide (threonyl-MDP);
      monophosphoryl lipid A (MPL); trehalose dimycolate (TDM); and the delipidated,
      deproteinized, cell wall skeleton (CWS) from either Mycobacterium phlei or the
      BCG strain of Mycobacterium bovis. Non-microbially derived adjuvants tested
      included aluminum hydroxide and the lipid amine CP-20,961. In guinea pigs, all
      adjuvants and adjuvant mixtures enhanced antibody titers to PA as well as
      survival after a parenteral challenge of virulent B. anthracis Ames spores. In
      contrast, PA alone or combined with either aluminum hydroxide or CP-20,961 failed
      to protect mice. Vaccines containing PA combined with threonyl-MDP or MPL-TDM-CWS
      protected a majority of female CBA/J mice. Statistical analysis of survival data 
      in the guinea pigs indicated that PA-MPL-CWS and PA-MPL-TDM-CWS were more
      efficacious than the currently licensed human anthrax vaccine.
AD  - Bacteriology Division, United States Army Medical Research Institute of
      Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011.
FAU - Ivins, B E
AU  - Ivins BE
FAU - Welkos, S L
AU  - Welkos SL
FAU - Little, S F
AU  - Little SF
FAU - Crumrine, M H
AU  - Crumrine MH
FAU - Nelson, G O
AU  - Nelson GO
LA  - eng
PT  - Journal Article
PL  - UNITED STATES
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Vaccines)
SB  - IM
MH  - Adjuvants, Immunologic/*administration & dosage
MH  - Animals
MH  - Anthrax/*prevention & control
MH  - Antigens, Bacterial/*immunology
MH  - Bacillus anthracis/*immunology
MH  - Bacterial Vaccines/*administration & dosage/*immunology
MH  - Female
MH  - Guinea Pigs
MH  - Immunization
MH  - Male
MH  - Mice
MH  - Mice, Inbred CBA
PMC - PMC257681
OID - NLM: PMC257681
EDAT- 1992/02/01
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PST - ppublish
SO  - Infect Immun. 1992 Feb;60(2):662-8.